PPE and Engineering Controls

Personal protective equipment and engineering controls for preparing hazardous drugs

Personal protective equipment and engineering controls for preparing hazardous drugs
Formulation Activity Double chemo-therapy gloves Protective gown Eye/face protection Respiratory protection Ventilated engineering control
All types of hazardous drugs Receiving, unpacking, and placing in storage No (single glove can be used, unless spills occur) Yes, when spills and leaks occur No Yes, when spills and leaks occur No
Tablets or capsules Cutting, crushing, or manipulating tablets or capsules; handling uncoated tablets Yes Yes No Yes, it not done in a control device Yes
Oral liquid drug or feeding tube Compounding Yes Yes Yes, if not done in a control device Yes, if not done in a control device Yes
Topical drug Compounding Yes Yes Yes, if not done in a control device Yes, if not done in a control device Yes, BSC or CACI (Note: carmustine and mustargen are volatile)
Subcutaneous/
intra-muscular injection from a vial
Preparation (Withdrawing from vial) Yes Yes Yes, if not done in a control device Yes, if not done in a control device Yes, BSC or CACI
Withdrawing and / or mixing
intravenous or intramuscular solution
from a vial or ampoule
Compounding Yes Yes No No Yes, BSC or CACI; use of CSTD recommended
Solution for irrigation Compounding Yes Yes Yes, if not done in a control device Yes, if not done in a control device Yes, BSC or CACI; use of CSTD recommended
Powder / solution for inhalation /
aerosol treatment
Compounding Yes Yes Yes, if not done in a control device Yes, if not done in a control device Yes, BSC or CACI
Spills Cleaning Yes Yes Yes Yes N/A

Source: NIOSH [2016]. NIOSH list of antineoplastic and other hazardous drugs in healthcare settings, 2016. By Connor TH, MacKenzie BA, DeBord DG, Trout DB, O’Callaghan JP. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication Number 2016-161 (Supersedes 2014-138).

 

Personal protective equipment and engineering controls for administering hazardous drugs

Personal protective equipment and engineering controls for administering hazardous drugs
Formulation Activity Double chemo-therapy gloves Protective gown Eye/face protection Respiratory protection Ventilated engineering control
Intact tablet or capsule Administration from unit-dose package No (single glove can be used) No No No N/A
Tablets or Capsules Administration No (single glove can be used) No Yes, if vomit or potential to spit up No N/A
Oral liquid drug or feeding tube Administration Yes Yes Yes, if vomit or potential to spit up no N/A
Topical drug Administration Yes Yes Yes, if liquid that could splash Yes, if inhalation potential N/A
Subcutaneous/ intra-muscular injection from a vial Administration from prepared syringe Yes Yes Yes, if liquid that could splash no N/A
Withdrawing and/ or mixing intravenous or intramuscular solution from a vial of ampoule Administration of prepared solution Yes Yes Yes, if liquid that could splash no N/A; CSTD required per USP 800 if the dosage from allows
Solution for irrigation Administration (bladder, HIPEC, limb perfusion, etc.) Yes Yes Yes Yes N/A
Powder/ solution for inhalation/ aerosol treatment Powder/solution administration Yes Yes Yes, if liquid that could splash Yes, if inhalation potential N/A
  Aerosol adminsitration Yes Yes Yes Yes Yes, when applicable
Drugs and metabolites in body fluids Disposal and cleaning Yes Yes Yes, if liquid that could splash Yes, if inhalation potential N/A
Drug-contaminated waste Disposal and cleaning Yes Yes Yes, if liquid that could splash Yes, if inhalation potential N/A
Spills Cleaning Yes Yes Yes Yes N/A

Source: NIOSH [2016]. NIOSH list of antineoplastic and other hazardous drugs in healthcare settings, 2016. By Connor TH, MacKenzie BA, DeBord DG, Trout DB, O’Callaghan JP. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication Number 2016-161 (Supersedes 2014-138).