Guidelines, policies and procedures for the use and manipulation of biohazards. Biosafety Manual (PDF)
Experiments involving biological materials must be registered in Click compliance system Click
Guidance for biohazard waste generators Biohazardous Waste Management Plan (PDF)
Biosafety Tips & Tricks Biosafety News
Good microbiological and laboratory practices are essential for a safe work environment. All personnel working in a laboratory handling biological materials take the appropriate biological safety-related trainings offered by the EHS.
Personnel working in BSL1+ should register for the Biosafety Principles learning track in Ability LMS, and complete online training annually.
In addition, all personnel working with RG-2 or 3 agents or at BSL-2 or 3 should receive adequate laboratory specific training from the Principal Investigator (PI) or laboratory supervisor.
Site-Specific Training Checklists
Fundamentals of Centrifuge Safety
Example forms:
Once you have completed one of the above forms, please email it to ehs@msu.edu, Attention Bio-safety Office.
Because the infectious nature of prions is not well characterized and destruction of these particles goes beyond the techniques typically required for biohazard inactivation, work with these agents requires special considerations for biocontainment to minimize both occupational and environmental exposure risk. Any researchers working with select agents must contact the EHS biosafety team.
MSU Guidelines for Handling Prions and Prion-Infected Tissues
All individuals who possess select agents must register with the CDC and/or APHIS through the designated institutional responsible official (RO). At MSU, the EHS Director and Biosafety Officer serve in this capacity. Any researchers working with select agents must contact the EHS biosafety team.
Reference
Investigators intending to work with Mycobacterium sp. in the laboratory must contact the EHS biosafety team well in advance. Propagation and/or manipulation of Mycobacterium tuberculosis and M. bovis cultures in the laboratory or animal room must be performed at BSL-3.
Reference
Infectious agents and toxins that appear on this list are considered by the Centers for Disease Control (CDC) or the United State Department of Agriculture (USDA) as having the potential to pose substantial harm or a severe threat to human, animal or plant health or plant products.
Possession and transfer of materials on this list (with the possible exception of toxins) requires registration with, and approval of the appropriate regulatory authority by way of the MSU Responsible Official prior to undertaking such activities. More information regarding select agents/high consequence pathogens requirements is available at http://www.selectagents.gov.
The importation, possession, or use of these agents is prohibited or restricted by law or by U.S. Department of Agriculture regulations or administrative policies.
These are transmissible diseases and toxicological conditions of animals that have the potential for serious consequences to human and/or animals either because of health or economic impacts.
List of Michigan Department of Agriculture Reportable Animal Diseases
These are biological agents known to infect humans as well as selected animal agents that may pose theoretical risks if inoculated into humans. Work with these agents is likely to require BSL-2 containment conditions as a minimum. Shipping or receiving these agents internationally is also likely to require a permit.
NIH Guidelines Appendix B: Biological Agents by Risk Group
For more information ragarding import permits for agents infectious to humans, please go to http://www.cdc.gov/od/eaipp/.
For information regarding import of animal-derived materials that may contain infectious agents, or any zoonotic agents on the list, please go to http://www.aphis.usda.gov/import_export/index.shtml.
For information regarding export of any materials on this list, please go to the Department of Commerce at http://www.commerce.gov.
The agents listed in this table are considered to be environmental release threats to agriculture by the USDA. To work with these agents or ship them across state lines or internationally, a USDA Plant Pathogen & Quarantine (PPQ) permit outlining conditions of use and containment requirements is likely to be required. For information regarding PPQ permits, please go to http://www.aphis.usda.gov/ppq/permits.
Work with these human-derived materials requires compliance with the Bloodborne Pathogens standard (references: OSHA, MIOSHA)
All personnel at risk of exposure must be included in the MSU BBP Exposure Control Program that requires initial and annual retraining and offer of the hepatitis B vaccination program. Please review the information on the bloodborne pathogens section of the EHS website and/or contact EHS.
Laboratory manipulations of these materials must be minimally conducted at BSL-2, which requires completion of biosafety training through EHS and specific facility and administrative controls. A summary of BSL-2 requirements can be found in Section VIII of the CDC/NIH BMBL (PDF).
The following items also bear additional regulatory consideration based on inherent risks associated with the nature of the source or the need for biocontainment of genetically modified organisms.
Need assistance? Contact the Biosafety Officer